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Discovery and characterization of cell-permeable inhibitors of <i>Leishmania mexicana</i> CLK1 using an in-cell target engagement assay

2025-06-19

Abstract excerpt

Leishmaniasis is a neglected tropical disease with limited treatment options and significant unmet medical need. Here, we report the development of a bioluminescence resonance energy transfer (BRET)-based target engagement assay in live intact cells to identify and validate cell-permeable, ATP-competitive inhibitors of Leishmania mexicana (Lmx)CLK1. LmxCLK2, a closely related paralogue with an identical protein k...

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Literature Corpus work
964c8b08-856c-50ea-b0b0-0b28090bdec3
DOI
10.1101/2025.06.17.659316
Open publication

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Discovery and characterization of cell-permeable inhibitors of <i>Leishmania mexicana</i> CLK1 using an in-cell target engagement assayDOI 10.1101/2025.06.17.659316
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