Article

Analysis of LmxMPK2 and LmxGSK3-β, two protein kinases important for the survival of Leishmania mexicana

2013-01-01

Abstract excerpt

Leishmaniasis is a tropical disease affecting around 12 million people worldwide with a further 350 million people at risk. Two million new cases are identified every year with an estimated 60,000 fatalities. Treatments have changed little in the past century and often patients are treated with increasingly ineffective and highly toxic drugs, thus highlighting the requirement for safer and more effective medicatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c85f69d3-90d6-538d-8ccc-4c179151c05a
DOI: 10.48730/5nfc-xw16

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of LmxMPK2 and LmxGSK3-β, two protein kinases important for the survival of Leishmania mexicanaDOI 10.48730/5nfc-xw16Read

Homologues of LMPK, a mitogen-activated protein kinase from Leishmania mexicana, in different Leishmania species.Semantic proximity Read

Repurposing approved protein kinase inhibitors as potent anti-leishmanials targeting Leishmania MAP kinasesSemantic proximity Read

Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival.Semantic proximity Read

Analysis of Leishmania GSK3 beta signalling pathwaysSemantic proximity Read

Interacting protein kinases involved in the regulation of flagellar length.Semantic proximity Read

CDPK2A and CDPK1 form a signaling module upstream of Toxoplasma motilitySemantic proximity Read

Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses.Semantic proximity Read

Protein kinase involved in flagellar-length control.Semantic proximity Read

Leishmania mexicana phosphoproteomicsSemantic proximity Read

The low complexity regions in the C-terminus are essential for the subcellular localisation of <i>Leishmania</i> casein kinase 1 but not for its activitySemantic proximity Read

SILAKin: A novel high throughput SILAC and mass spectrometry-based assay to identify the substratome of kinases secreted by pathogensSemantic proximity Read

Studies on the kinome of Plasmodium falciparum and biochemical characterization of atypical protein kinasesSemantic proximity Read