Article

Using machine learning to dissect host kinases required for <i>Leishmania</i> internalization and development

2024-05-16

Abstract excerpt

The Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host, promastigotes are engulfed by phagocytes ( i.e. , neutrophils, dendritic cells, and macrophages) to establish infection. When these phagocytes die or break down, amastigotes must be re-internalized to survive within the acidic phagolysosome and establish dise...

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Literature Corpus work: c28e8919-fd6c-55c9-bb81-7145799a69da
DOI: 10.1101/2024.05.16.593986

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