Article

Targeting <i>Echinococcus multilocularis</i> PIM kinase for improving anti-parasitic chemotherapy

2022-05-12

Abstract excerpt

<h4>Background</h4> The potentially lethal zoonosis alveolar echinococcosis (AE) is caused by the metacestode larval stage of the tapeworm Echinococcus multilocularis . Current AE treatment options are limited and rely on surgery as well as on chemotherapy involving benzimidazoles (BZ). BZ treatment, however, is parasitostatic only, must be given for prolonged time periods, and is associated with adverse side ef...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 268e8e3e-ce64-5fc1-bcf7-76c7311ea22a
DOI: 10.1101/2022.05.12.491592

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting <i>Echinococcus multilocularis</i> PIM kinase for improving anti-parasitic chemotherapyDOI 10.1101/2022.05.12.491592Read

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in <i>P. falciparum</i> MalariaSemantic proximity Read

EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation of Echinococcus multilocularis germinative cells via the EGFR-ERK pathwaySemantic proximity Read

Mammalian deubiquitinating enzyme inhibitors display <i>in vitro</i> and <i>in vivo</i> activity against malaria parasites and potentiate artemisinin actionSemantic proximity Read

Evolution and inhibition of the FIKK effector kinase family in <i>P. falciparum</i>Semantic proximity Read

Polo-like kinase 1 regulates growth in juvenile <i>Fasciola hepatica</i>Semantic proximity Read

Fighting Tumor Cell Survival: Advances in the Design and Evaluation of Pim InhibitorsSemantic proximity Read

Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote.Semantic proximity Read

Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profilesSemantic proximity Read

Genome-wide transcriptome analysis of Echinococcus multilocularis larvae and germinative cell cultures reveals genes involved in parasite stem cell functionSemantic proximity Read

EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and developmentSemantic proximity Read

Mapping the genome of <i>Plasmodium falciparum</i> on the drug-like chemical space reveals novel anti-malarial targets and potential drug leadsSemantic proximity Read

Regulation of Hepatic MicroRNAs in Response to Early Stage <i>Echinococcus multilocularis</i> Egg Infection in C57BL/6 miceSemantic proximity Read