Article

Copy number losses of oncogenes and gains of tumor suppressor genes generate common driver events of human cancer

2023-08-07

Abstract excerpt

<h4>ABSTRACT</h4> Cancer driver genes can be under positive selection for various types of genetic alterations, including gain-of-function or loss-of-function point mutations (single-nucleotide variants, SNV), small indels, copy number alterations (CNA) and other structural variants. We studied the landscape of interactions between these different types of alterations affecting the same gene by a statistical meth...

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Literature Corpus work: 39387d78-359f-5413-a764-6d66b0484a3d
DOI: 10.1101/2023.08.05.552104

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