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Maladaptation after a virus host switch leads to increased activation of the pro-inflammatory NF-κB pathway

12 May 2022

Abstract excerpt

Myxoma virus (MYXV) causes localized cutaneous fibromas in its natural hosts, tapeti and brush rabbits; however, in the European rabbit, MYXV causes the lethal disease myxomatosis. Currently, the molecular mechanisms underlying this increased virulence after cross-species transmission are poorly understood. In this study, we investigated the interaction between MYXV M156 and the host protein kinase R (PKR) to...

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PMID: 35549551
DOI: 10.1073/pnas.2115354119

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