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Article

A Novel Inhibitor of the NF-κB Signaling Pathway Encoded by the Parapoxvirus Orf Virus

11 Feb 2010

Abstract excerpt

The parapoxvirus orf virus (ORFV) is a pathogen of sheep and goats that has been used as a preventive and therapeutic immunomodulatory agent in several animal species. However, the functions (genes, proteins, and mechanisms of action) evolved by ORFV to modulate and manipulate immune responses are poorly understood. Here, the novel ORFV protein ORFV024 was shown to inhibit activation of the NF-kappaB signaling...

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PMID: 20147406
DOI: 10.1128/jvi.02291-09

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A Novel Inhibitor of the NF-κB Signaling Pathway Encoded by the Parapoxvirus Orf VirusPMID 20147406Read ↗

Orf Virus <i>ORFV121</i> Encodes a Novel Inhibitor of NF-κB That Contributes to Virus VirulenceSemantic proximity Read ↗

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Orf virus ORFV112, ORFV117 and ORFV127 contribute to ORFV IA82 virulence in sheep.Semantic proximity Read ↗

A homolog of interleukin-10 is encoded by the poxvirus orf virusSemantic proximity Read ↗

Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factorSemantic proximity Read ↗

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