Article

Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific Fashion

2024-06-07

Abstract excerpt

Yaba monkey tumor virus (YMTV) and Tanapox virus (TPV) are members of the Yatapoxvirus genus and can infect humans and other primates. Despite the threat posed by yatapoxviruses, the factors determining their host range are poorly understood. In this study, we analyzed the ability of YMTV and TPV orthologs of vaccinia virus K3 (called 012 in YMTV and TPV), which share 75% amino acid identity with one another, to i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94ba7706-e183-5cfe-b9f4-6e3957ef4217
DOI: 10.20944/preprints202406.0459.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tanapox Virus and Yaba Monkey Tumor Virus K3 Orthologs Inhibit Primate Protein Kinase R in a Species-Specific FashionDOI 10.20944/preprints202406.0459.v1Read

Orthopoxvirus K3 orthologs show virus- and host-specific inhibition of the antiviral protein kinase PKRSemantic proximity Read

Comparative Analysis of Poxvirus Orthologues of the Vaccinia Virus E3 Protein: Modulation of Protein Kinase R Activity, Cytokine Responses, and Virus PathogenicitySemantic proximity Read

Complete Genomic Sequence and Comparative Analysis ofthe Tumorigenic Poxvirus Yaba Monkey TumorVirusSemantic proximity Read

A Single Amino Acid Dictates Protein Kinase R Susceptibility to Unrelated Viral Antagonists.Semantic proximity Read

Poxvirus K3 Orthologs Regulate NF-kB-Dependent Inflammatory Responses by Targeting the PKR–eIF2a Axis in Multiple SpeciesSemantic proximity Read

Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors.Semantic proximity Read

Systematic characterization of the local evolutionary space available to human PKR and vaccinia virus K3Semantic proximity Read

The Vaccinia Virus B12 Pseudokinase Represses Viral Replication via Interaction with the Cellular Kinase VRK1 and Activation of the Antiviral Effector BAF.Semantic proximity Read

Adaptive Gene Amplification As an Intermediate Step in the Expansion of Virus Host RangeSemantic proximity Read

Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic.Semantic proximity Read

Adaptive duplication and functional diversification of Protein kinase R contribute to the uniqueness of bat-virus interactionsSemantic proximity Read