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The mechanism and consequences of amyloid-β modulating thiamine pyrophosphokinase-1 expression in microglia

2024-09-19

Abstract excerpt

Ample studies attribute cognitive decline in Alzheimer’s disease to amyloid-β deposition 1–6 . However, brain amyloid-β accumulation that saturates years before the manifestation of clinical symptoms is dissociated with cognitive decline of the disease 7 . It is unknown how these two processes are mechanistically linked. In this and our accompanied study, we report that thiamine pyrophosphokinase-1 (TPK) deficie...

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Literature Corpus work
96379148-ae7b-568e-a4c2-4a3fae4e7d0d
DOI
10.1101/2024.09.18.613405
Open publication

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The mechanism and consequences of amyloid-β modulating thiamine pyrophosphokinase-1 expression in microgliaDOI 10.1101/2024.09.18.613405
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