Article

PTP1B inhibition promotes microglial phagocytosis in Alzheimer’s disease models by enhancing SYK signaling

2025-05-31

Abstract excerpt

Amyloid-β (Aβ) accumulation is a hallmark of Alzheimer’s disease (AD). Emerging evidence suggests that impaired microglial Aβ phagocytosis is a key feature in AD, highlighting the therapeutic potential of enhancing this innate immune function. Here, we demonstrate that genetic deletion or pharmacological inhibition of protein tyrosine phosphatase 1B (PTP1B) ameliorated memory deficits and reduced Aβ burden in APP/...

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Literature Corpus work: 57863bb1-ef7b-5375-ba91-6f381428e9a0
DOI: 10.1101/2025.05.30.657101

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