Article

β-catenin-regulated Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosis

2023-10-19

Abstract excerpt

<title>Abstract</title> <p>Chronic kidney disease (CKD) is in high prevalence all over the world. Renal fibrosis is the common feature in all kinds of CKD. However, the underlying mechanisms of renal fibrosis are still poorly understood. Fatty acid metabolism is a key pathway to supply energy to tubular cells. However, the regulatory machinery has not been fully investigated. In this study, we found the inhibitio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4a58adec-007e-5125-83aa-ec52b8777d3e
DOI: 10.21203/rs.3.rs-3313924/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

β-catenin-regulated Sumoylation modification of LKB1 and fatty acid metabolism is critical in renal fibrosisDOI 10.21203/rs.3.rs-3313924/v1Read

Fibulin-2 transduces a matrix-to-metabolism signal in kidney fibrosisSemantic proximity Read

Chronic kidney disease exacerbates hyperlipidemia and atherosclerosis via miR-148a-3p targeting SIK1/AMPKα1 in liverSemantic proximity Read

Role of HAO2 in rats with chronic kidney disease by regulating fatty acid metabolic processes in renal tissueSemantic proximity Read

Ablation of the Renal Tubular Gluconeogenic Enzyme PCK1 Drives AKI-to-CKD Transition by Negatively Regulating the TGF-β/Smad3 Signaling PathwaySemantic proximity Read

Kidney single-cell transcriptomes uncover SGLT2i-induced metabolic reprogramming via restoring glycolysis and fatty acid oxidationSemantic proximity Read

LKB1 and cancer: The dual role of metabolic regulation.Semantic proximity Read

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasisSemantic proximity Read

Metformin's Effect on Non-Alcoholic Fatty Liver Disease through the miR-200a-5p and AMPK/SERCA2b PathwaySemantic proximity Read

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signallingSemantic proximity Read

Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressorSemantic proximity Read

MiR-9-5p protects from kidney fibrosis by metabolic reprogrammingSemantic proximity Read

Silencing of STE20-type kinase TAOK1 confers protection against hepatocellular lipotoxicity through metabolic rewiringSemantic proximity Read