Article

Pharmacological evaluation of novel non-nucleotide purine derivatives as P2X7R antagonists for the treatment of neuroinflammation in traumatic brain injury

2024-09-21

Abstract excerpt

<h4>Background: </h4> and purpose. Traumatic brain injury (TBI) is an acute brain lesion considered as one of the leading causes of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage-associated molecular patterns, such as ATP release, recognized by P2X7 purinergic receptors (P2X7R). The P2X7R-NLRP3 inflammasome axis has been identified as one of the main actor...

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Literature Corpus work: 962e0437-2a58-5507-9eb0-30683e9a17ad
DOI: 10.22541/au.172690078.81456035/v1

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