Thalamic Purinergic Receptors: A Gateway to Modulating Fibromyalgia Pain via NLRP3 Inflammasome Signaling and Pyroptosis

Abstract excerpt

<title>Abstract</title> <p>The high pain sensitivity in fibromyalgia (FM) is processed by the thalamus that presents as a key component in the pain pathway in FM patients. Noteworthy, Purinergic receptors, specifically P2X, are implicated in pain signaling and neuroinflammation via inflammasome signaling. However, there is no available data on the impact of pharmacological intervention on P2X receptor in thalamic...

Topics

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• Antioxidants
• Biomarkers
• Disease Management
• Disease Susceptibility
• Epigenesis, Genetic
• Fibromyalgia
• Pain Management
• Serologic Tests

Identifiers and source

Literature Corpus work

485f96fc-6b7d-53a2-9b7a-774597a66818

DOI

10.21203/rs.3.rs-4560073/v1