Article

Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS

2020-03-18

Abstract excerpt

Microglial cells, the resident macrophages of the CNS, exist in a process-bearing, ramified/surveying phenotype under resting conditions. Upon activation by cell damaging factors they get transformed to an amoeboid phenotype releasing various cell products including pro-inflammatory cytokines, chemokines, proteases, reactive oxygen/nitrogen species and the excytotoxic ATP and glutamate. In addition, they engulf pa...

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Literature Corpus work: e4e19a78-0fb4-5a5e-a0df-1e3d4514e17c
DOI: 10.20944/preprints202003.0288.v1

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