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Article

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation.

Cell reports - 9 May 2017

Shinozaki Youichi, Shibata Keisuke, Yoshida Keitaro, Shigetomi Eiji, Gachet Christian, Ikenaka Kazuhiro, Tanaka Kenji F, Koizumi Schuichi

Abstract excerpt

Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity and its relation to pathophysiology are unclear. Here, we show that microglia transform astrocytes into a neuroprotective phenotype via downregulation of the P2Y1 purinergic receptor. TBI initially caused microglial activation in the injury core, followed by reactive astrogliosis in the...

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Identifiers

PMID: 28494865
DOI: 10.1016/j.celrep.2017.04.047

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