Article

Synthetic Cannabinoids and the Purinergic–Dopaminergic Axis: P2X7 as a Primary Sensor of Neuroinflammatory Injury and the Role of Adenosine Receptor Heteromers in Emerging NPS Toxicity

2026-08-12

Abstract excerpt

Synthetic cannabinoids (SCs), marketed as Spice, K2, and dozens of successor compounds, constitute one of the most pharmacologically dangerous categories of new psychoactive substances (NPS) currently in circulation. Their extreme toxicity relative to Δ9-tetrahydrocannabinol (THC) cannot be explained by CB1 receptor pharmacokinetics alone. This review proposes that the purinergic signaling system, specifically the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72de28c3-7cab-52fd-ae8b-6a5e47be0a81
DOI: 10.20944/preprints202608.0802.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synthetic Cannabinoids and the Purinergic–Dopaminergic Axis: P2X7 as a Primary Sensor of Neuroinflammatory Injury and the Role of Adenosine Receptor Heteromers in Emerging NPS ToxicityDOI 10.20944/preprints202608.0802.v1Read

From Synaptic Plasticity to Neurotoxicity: Endocannabinoid Influence on Addiction and NeurodegenerationSemantic proximity Read

Pharmacological evaluation of novel non-nucleotide purine derivatives as P2X7R antagonists for the treatment of neuroinflammation in traumatic brain injurySemantic proximity Read

Cannabidiol in Neurology: Current Insights and Translational PerspectivesSemantic proximity Read

PrPC signalling in neurons: From basics to clinical challengesSemantic proximity Read

Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNSSemantic proximity Read

Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathySemantic proximity Read

Endogenous Neurotoxicity: A Pathophysiological Consequence of Homeostatic DysfunctionSemantic proximity Read

An enquiry to the role of CB1 receptors in neurodegenerationSemantic proximity Read

Translational and Clinical Pharmacology Considerations in Drug Repurposing for X-linked Adrenoleukodystrophy-A Rare Peroxisomal DisorderSemantic proximity Read

Thalamic Purinergic Receptors: A Gateway to Modulating Fibromyalgia Pain via NLRP3 Inflammasome Signaling and PyroptosisSemantic proximity Read

Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channelSemantic proximity Read

The Mapping of Physiological Conversion Pathways from the Major Acidic CannabinoidsSemantic proximity Read