Article

Altered Inflammasome and Immune activation in Paediatric Traumatic Brain Injury

2024-03-29

Abstract excerpt

<h4>Introduction: </h4> Systemic Inflammation is associated with Traumatic Brain Injury (TBI) and therefore is a potential target for immunomodulation. Dysregulated immune function post-TBI increased susceptibility to infection and post-concussive syndrome. The inflammasome is a protein complex associated with an amplified proinflammatory response and is a potential target for immunomodulation that preserves antim...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c3d66815-89ed-5d1a-8eea-f52e697984a9
DOI: 10.21203/rs.3.rs-4172622/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Altered Inflammasome and Immune activation in Paediatric Traumatic Brain InjuryDOI 10.21203/rs.3.rs-4172622/v1Read

A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomesSemantic proximity Read

NLRP3 inhibition maintains microglia architecture and enhances behavioral recovery after traumatic brain injurySemantic proximity Read

Repetitive mild traumatic brain injury elicits a reactive microglial morphology and elevates serum neurofilament light levels, independent of NLRP3 inflammasome inhibitionSemantic proximity Read

Oxytocin release modulates acute neuroinflammation and improves brain development after pediatric traumatic brain injurySemantic proximity Read

Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain InjurySemantic proximity Read

Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort studySemantic proximity Read

Blood-Based CNS-Injury and Inflammation Biomarkers Sampled at Acute, Subacute, and Chronic phases After Mild TBI Demonstrate Diagnostic Utility For Patients With and Without Intracranial Injuries on Acute CT and MRISemantic proximity Read

Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury.Semantic proximity Read

ASC contributes to sustained neuroinflammation and mild cognitive impairment after closed-head injurySemantic proximity Read

Cerebrospinal Fluid Mitochondrial DNASemantic proximity Read

TLR4-pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injurySemantic proximity Read

A proteomics-based approach reveals the role of the activation of astrocytes with the A1 phenotype in medullary neuroinflammation after TBI in mice.Semantic proximity Read