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Article

Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1.

Genes & development - 15 Jul 2014

Wu Jingyan, Hopper Anita K

Abstract excerpt

In eukaryotes and archaea, tRNA splicing generates free intron molecules. Although ∼ 600,000 introns are produced per generation in yeast, they are barely detectable in cells, indicating efficient turnover of introns. Through a genome-wide search for genes involved in tRNA biology in yeast, we uncovered the mechanism for intron turnover. This process requires healing of the 5' termini of linear introns by the...

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Identifiers

PMID: 25030695
DOI: 10.1101/gad.244673.114
PMCID: PMC4102763

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Source receipt: pubmed, retrieved 7 Sept 2026.

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