Article

Biochemical and structural insights into a 5’ to 3’ RNA ligase reveal a potential role in tRNA ligation

2024-04-24

Abstract excerpt

ATP-grasp superfamily enzymes contain a hand-like ATP-binding fold and catalyze a variety of reactions using a similar catalytic mechanism. More than 30 protein families are categorized in this superfamily, and they are involved in a plethora of cellular processes and human diseases. Here we identify C12orf29 as an atypical ATP-grasp enzyme that ligates RNA. Human C12orf29 and its homologs auto-adenylate on an act...

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Literature Corpus work: 1a0c042b-7ea9-5709-ab06-682bd6ec0c69
DOI: 10.1101/2024.04.24.590974

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Biochemical and structural insights into a 5’ to 3’ RNA ligase reveal a potential role in tRNA ligationDOI 10.1101/2024.04.24.590974Read

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