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Article

DNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes.

Nucleic acids research - 11 Mar 2015

Andrade-Lima Leonardo C, Veloso Artur, Paulsen Michelle T, Menck Carlos F M, Ljungman Mats

Abstract excerpt

The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5'-3' direction with slow recovery and TC-NER at the 3' end of long genes. RNA synthesis resumed fully at the 3'-end of genes after...

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Identifiers

PMID: 25722371
DOI: 10.1093/nar/gkv148
PMCID: PMC4357734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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