Article

RNA Transcripts Serve as a Template for Double-Strand Break Repair in Human Cells

2025-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Double-strand breaks (DSBs) are toxic lesions that lead to genome instability. While canonical DSB repair pathways typically operate independently of RNA, emerging evidence suggests that RNA:DNA hybrids and transcripts near damaged sites can influence repair outcomes. However, a direct role for transcript RNA as a template during DSB repair in human cells is yet to be established. In this study,...

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Literature Corpus work: 695a6b66-588f-5939-a994-1e098956714a
DOI: 10.1101/2025.02.23.639725

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