Article

Loss of neuronal lysosomal acid lipase drives amyloid pathology in Alzheimer’s disease

2024-06-10

Abstract excerpt

Underlying drivers of late-onset Alzheimer’s disease (LOAD) pathology remain unknown. However, multiple biologically diverse risk factors share a common pathological progression. To identify convergent molecular abnormalities that drive LOAD pathogenesis we compared two common midlife risk factors for LOAD, heavy alcohol use and obesity. This revealed that disrupted lipophagy is an underlying cause of LOAD pathoge...

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Literature Corpus work: 95f60482-a9d1-5654-a5f2-2e14806fbdf2
DOI: 10.1101/2024.06.09.596693

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