Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

27 Dec 2016

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia, and its prevalence will increase significantly in the coming decades. Although important progress has been made, fundamental pathogenic mechanisms as well as most hereditary contributions to the sporadic form of the disease remain unknown. In this review, we examine the now substantial links between AD pathogenesis and lysosomal biology. The lysosome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cellular transport and secretion
Share to Lysosomal Storage Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28027395
DOI: 10.1111/jnc.13935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?PMID 28027395Read ↗

The neuronal endosomal-lysosomal system in Alzheimer's diseaseSemantic proximity Read ↗

Neurodegenerative lysosomal disorders: A continuum from development to late ageSemantic proximity Read ↗

Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's diseaseSemantic proximity Read ↗

Alzheimer's Disease-Related Misfolded Proteins and Dysfunctional Organelles on Autophagy MenuSemantic proximity Read ↗

Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesisSemantic proximity Read ↗

Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkersSemantic proximity Read ↗

The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A ReviewSemantic proximity Read ↗

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factorsSemantic proximity Read ↗

Brain Disorders Due to Lysosomal DysfunctionSemantic proximity Read ↗

Autophagic dysfunction in Alzheimer’s disease: Cellular and molecular mechanistic approaches to halt Alzheimer’s pathogenesisSemantic proximity Read ↗

The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)Semantic proximity Read ↗

Autophagy and Alzheimer’s Disease: Mechanisms and Impact Beyond the BrainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.