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The neuronal endosomal-lysosomal system in Alzheimer's disease

5 Mar 2001

Abstract excerpt

Robust activation of the neuronal lysosomal system and cellular pathways converging on the lysosome, such as the endocytic and autophagic pathways, are prominent neuropathological features of Alzheimer's disease. Disturbances of the neuronal endocytic pathway, which are one of the earliest known intracellular changes occurring in Alzheimer's disease and Down syndrome, provide insight into how beta-amyloidogenesis...

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Identifiers

PMID: 12214078
DOI: 10.3233/jad-2001-3114

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