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The contribution of preclinical magnetic resonance imaging and spectroscopy to Huntington’s disease

13 Feb 2024

Abstract excerpt

Huntington's disease is an inherited disorder characterized by psychiatric, cognitive, and motor symptoms due to degeneration of medium spiny neurons in the striatum. A prodromal phase precedes the onset, lasting decades. Current biomarkers include clinical score and striatal atrophy using Magnetic Resonance Imaging (MRI). These markers lack sensitivity for subtle cellular changes during the prodromal phase. MRI...

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PMID: 38414634
DOI: 10.3389/fnagi.2024.1306312

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