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Article

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease.

Human molecular genetics - 1 May 2015

Jin Jing, Peng Qi, Hou Zhipeng, Jiang Mali, Wang Xin, Langseth Abraham J, Tao Michael, Barker Peter B, Mori Susumu, Bergles Dwight E, Ross Christopher A, Detloff Peter J, Zhang Jiangyang, Duan Wenzhen

Abstract excerpt

White matter abnormalities have been reported in premanifest Huntington's disease (HD) subjects before overt striatal neuronal loss, but whether the white matter changes represent a necessary step towards further pathology and the underlying mechanism of these changes remains unknown. Here, we characterized a novel knock-in mouse model that expresses mouse HD gene homolog (Hdh) with extended CAG repeat- HdhQ250,...

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Identifiers

PMID: 25609071
DOI: 10.1093/hmg/ddv016
PMCID: PMC4383863

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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