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Article

Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model.

NeuroImage - 1 Jun 2011

Cheng Yong, Peng Qi, Hou Zhipeng, Aggarwal Manisha, Zhang Jiangyang, Mori Susumu, Ross Christopher A, Duan Wenzhen

Abstract excerpt

Huntington's disease (HD) displays progressive striatal atrophy that occurs long before the onset of clinical motor symptoms. As there is no treatment for the disease once overt symptoms appear, it has been suggested that neuroprotective therapy given during this presymptomatic period might slow progression of the disease. This requires biomarkers that can reliably detect early changes and are sensitive to...

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Identifiers

PMID: 21320608
DOI: 10.1016/j.neuroimage.2011.02.022
PMCID: PMC3372851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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