Article

Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington’s disease: Evidence from in vivo ultra-strong gradient MRI

2021-11-30

Abstract excerpt

White matter (WM) alterations have been observed early in Huntington’s disease (HD) progression but their role in the disease-pathophysiology remains unknown. We exploited ultra-strong-gradient MRI to tease apart contributions of myelin (with the magnetization transfer ratio), and axon density (with the restricted volume fraction from the Composite Hindered and Restricted Model of Diffusion) to WM differences betw...

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Literature Corpus work: ed7c5233-8f5d-515f-bf4e-095cf5771db4
DOI: 10.1101/2021.11.29.469517

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Mutation-related apparent myelin, not axon density, drives white matter differences in premanifest Huntington’s disease: Evidence from <i>in vivo</i> ultra-strong gradient MRI

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