Article

Proton-Activated Chloride Channel 1 (PACC1) is essential for innate host defense against bacterial sepsis

2026-01-02

Abstract excerpt

Bacterial sepsis remains a devastating clinical problem. Here, we describe a protective role for the recently discovered acid-sensitive, proton-activated chloride channel, PACC1 (PAC/ASOR/TMEM206), during sepsis. Initially, we found PACC1 was enriched in healthy human and mouse mononuclear phagocytes, particularly macrophages, and differentially regulated by inflammatory stimuli, suggesting PACC1 involvement in in...

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Literature Corpus work: 95e15e10-67cb-5dea-a0f8-977674edcdae
DOI: 10.64898/2025.12.31.697179

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