Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LPS mediates cuproptosis and inflammation in THP-1 macrophages through HKDC1

10 Jun 2025

Abstract excerpt

Cuproptosis is a recently identified form of copper-driven cell death characterized by the aggregation of acylated proteins and proteotoxic stress in the mitochondrial tricarboxylic acid cycle, which plays a role in inflammation. Recent studies suggest that hexokinase structural domain protein 1 (HKDC1), a fifth hexokinase, is involved in regulating mitochondrial function. However, the role of HKDC1 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune cells in cancer
Share to Inflammatory Biomarkers in Disease Prognosis
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40692442
DOI: 10.3724/abbs.2025089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LPS mediates cuproptosis and inflammation in THP-1 macrophages through HKDC1PMID 40692442Read ↗

Identification of immune characteristic biomarkers and therapeutic targets in cuproptosis for sepsis by integrated bioinformatics analysis and single-cell RNA sequencing analysisSemantic proximity Read ↗

Identification of potential biomarkers of cuproptosis in cerebral ischemiaSemantic proximity Read ↗

Identification and experimental validation of cuproptosis regulatory program in a sepsis immune microenvironment through a combination of single-cell and bulk RNA sequencingSemantic proximity Read ↗

Integrated bioinformatics and experiment validation reveal cuproptosis-related biomarkers and therapeutic targets in sepsis-induced myocardial dysfunctionSemantic proximity Read ↗

Cuproptosis: potential new direction in diabetes research and treatmentSemantic proximity Read ↗

Cuproplasia and cuproptosis, two sides of the coinSemantic proximity Read ↗

Emerging insights into cuproptosis and copper metabolism: implications for age-related diseases and potential therapeutic strategiesSemantic proximity Read ↗

Cuproptosis-Related Genes as Prognostic Biomarkers for Sepsis: Insights into Immune Function and Personalized ImmunotherapySemantic proximity Read ↗

Role and mechanisms of cuproptosis in the pathogenesis of Wilson's disease (Review)Semantic proximity Read ↗

Copper metabolism and cuproptosis in human malignancies: Unraveling the complex interplay for therapeutic insightsSemantic proximity Read ↗

A novel signature combing cuproptosis- and ferroptosis-related genes in sepsis-induced cardiomyopathySemantic proximity Read ↗

Kat2a-Mediated Histone Lactylation Promotes Ferroptosis and Inflammation in Sepsis-Associated Lung InjurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.