Article

FAM19A4 Enhances Neutrophil Respiratory Burst via p38 MAPK in Lethal Sepsis

2025-11-08

Abstract excerpt

Sepsis causes high mortality and resource strain, with neutrophil-derived reactive oxygen species (ROS) contributing to excessive inflammation. The secretory protein FAM19A4 modulates ROS release, but its role in sepsis was unclear. We measured elevated FAM19A4 levels in septic patients and cecal ligation and puncture (CLP) mice, correlating with increased mortality. Fam19a4 −/− mice subjected to CLP showed sign...

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Literature Corpus work: d8056bbd-1a21-5d55-a1f6-8715af49b0bc
DOI: 10.1101/2025.11.07.687190

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