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Macrophage Notch1 drives septic cardiac dysfunction by impairing mitophagy and promoting NLRP3 activation

26 May 2025

Abstract excerpt

Sepsis is a life-threatening condition with limited therapeutic options, characterized as excessive systemic inflammation and multiple organ failure. Macrophages play critical roles in sepsis pathogenesis. Although numerous studies support the critical role of Notch signaling in most inflammatory diseases, the function of Notch1 signaling in macrophages activation and its underlying molecular mechanism during...

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PMID: 40414862
DOI: 10.1186/s13062-025-00657-4

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