Article

Local genetic correlation analysis of Alzheimer’s disease and stroke implicates <i>PHLPP1</i> as a shared locus in individuals of African ancestry

2025-12-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Neuropathological studies indicate a strong association between Alzheimer’s disease (AD) and stroke, yet the molecular mechanisms underlying this association remain unclear. <h4>Methods</h4> Local genetic correlation analysis was conducted with LAVA using the results from genome-wide association studies on AD and stroke in individuals of African ancestry. Enhanced Hi-C Capt...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95d7334b-88e9-5686-86d2-9c902c204c5d
DOI: 10.64898/2025.12.03.25341552

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Local genetic correlation analysis of Alzheimer’s disease and stroke implicates <i>PHLPP1</i> as a shared locus in individuals of African ancestryDOI 10.64898/2025.12.03.25341552Read

Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.Semantic proximity Read

Pleiotropic effects of PLEC and C1Q on Alzheimer’s disease and cardiovascular traitsSemantic proximity Read

Extended genome-wide association study employing the African Genome Resources Panel identifies novel susceptibility loci for Alzheimer’s Disease in individuals of African ancestrySemantic proximity Read

Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes.Semantic proximity Read

Shared Biological Pathways Between Alzheimer’s Disease and Ischemic StrokeSemantic proximity Read

Integration of Alzheimer’s disease genetics and myeloid genomics reveals novel disease risk mechanismsSemantic proximity Read

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies<i>LRRC4C, LHX5-AS1</i>and nominates ancestry-specific loci<i>PTPRK</i>,<i>GRB14</i>, and<i>KIAA0825</i>as novel risk loci for Alzheimer’s disease: the Alzheimer’s Disease Genetics ConsortiumSemantic proximity Read

Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.Semantic proximity Read

Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.Semantic proximity Read

Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease.Semantic proximity Read

Multi-ancestry meta-analysis identifies 2 novel loci associated with ischemic stroke and reveals heterogeneity of effects between sexes and ancestriesSemantic proximity Read

Identification of 20 novel loci associated to ischemic stroke. Epigenome-Wide Association StudySemantic proximity Read