Article
Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2026
Ray Nicholas R, Kurup Jiji, Kumar Ajneesh, Rajabli Farid, Wang Liyong, Xu Wanying, Jin Fulai, Yilmaz Elanur, Kizil Caghan, Bertholim-Nasciben Luciana, Moura Sofia, Ramirez Aura M, Baiyewu Olusegun, Griswold Anthony J, Coker Motunrayo, Scott Kyle M, Akinwande Kazeem, Adams Larry D, Diala Samuel, Whitehead Patrice G, McCauley Jacob L, Ogunronbi Mayowa, Hamilton-Nelson Kara L, Damasceno Albertino, Zaman Andrew F, Blanton Susan H, Akpalu Albert, Cuccaro Michael L, Wahab Kolawole, McInerney Katalina F, Nuytemans Karen, Obiako Reginald, Mena Pedro R, Okubadejo Njideka, Martinez Izri M, Zewde Yared Z, Gugssa Seid A, Sarfo Fred S, Kalaria Raj, Ndetei David M, Williams Scott M, Caban-Holt Allison, Tosto Giuseppe, Haines Jonathan L, Akinyemi Rufus O, Ogunniyi Adesola, Byrd Goldie S, Bush William S, Kunkle Brian W, Vance Jeffery M, Pericak-Vance Margaret A, Reitz Christiane
Abstract excerpt
INTRODUCTION: Neuropathological studies indicate a strong association between Alzheimer's disease (AD) and stroke, yet the molecular mechanisms underlying this association remain unclear. METHODS: Local genetic correlation analysis was conducted with LAVA (Local Analysis of [co]Variant Annotation) using the results from genome-wide association studies on AD and stroke in individuals of African ancestry. Enhanced...
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