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The suppression of Brd4 inhibits peripheral plasma cell differentiation and exhibits therapeutic potential for systemic lupus erythematosus

2021-04-14

Abstract excerpt

<h4>Background: </h4> and purpose: To investigate the role of bromodomain-containing protein 4 (Brd4) in regulating B cell differentiation and its therapeutic potential for B cell-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). Experimental Approach: Human and murine B cells were purified and cultured with different stimuli. B cell surface markers, proliferation and apoptosis were estimate...

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Literature Corpus work
95d600d8-a182-5cb9-982a-e8b780ef3a26
DOI
10.22541/au.161841605.50547094/v1
Open publication

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The suppression of Brd4 inhibits peripheral plasma cell differentiation and exhibits therapeutic potential for systemic lupus erythematosusDOI 10.22541/au.161841605.50547094/v1
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