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Article

BRD4 is a novel therapeutic target for liver fibrosis

7 Dec 2015

Abstract excerpt

Liver fibrosis is characterized by the persistent deposition of extracellular matrix components by hepatic stellate cell (HSC)-derived myofibroblasts. It is the histological manifestation of progressive, but reversible wound-healing processes. An unabated fibrotic response results in chronic liver disease and cirrhosis, a pathological precursor of hepatocellular carcinoma. We report here that JQ1, a small...

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PMID: 26644586
DOI: 10.1073/pnas.1522163112

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