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Article

The path to biomarker-based diagnostic criteria for the spectrum of neurodegenerative diseases

18 Feb 2020

Abstract excerpt

Introduction: The postmortem examination still represents the reference standard for detecting the pathological nature of chronic neurodegenerative diseases (NDD). This approach displays intrinsic conceptual limitations since NDD represent a dynamic spectrum of partially overlapping phenotypes, shared pathomechanistic alterations that often give rise to mixed pathologies.Areas covered: We scrutinized the...

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PMID: 32066283
DOI: 10.1080/14737159.2020.1731306

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