Article

Senataxin is required for optimal class switch recombination to the immunoglobulin A isotype

2025-09-25

Abstract excerpt

Senataxin (SETX) is an RNA/DNA helicase that plays a pivotal role in transcription, R-loop resolution, and the DNA damage response (DDR). Dysfunction of SETX, however, has been implicated in neurodegenerative diseases, including amyotrophic lateral sclerosis and ataxia with oculomotor apraxia type 2. Importantly, both R-loop resolution and the DDR are essential for class switch recombination (CSR) in B cells, a cr...

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Identifiers and source

Literature Corpus work: 95c125db-c63d-50e8-850a-f60f424e4187
DOI: 10.1101/2025.09.23.678005

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