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Article

Multi-region sequencing depicts intratumor heterogeneity and clonal evolution in cervical cancer.

Medical oncology (Northwood, London, England) - 12 Jan 2023

Wang Chen, Bai Rui, Liu Yu, Wang Kun, Wang Yu, Yang Jian, Cai Haoyang, Yang Ping

Abstract excerpt

Cervical cancer is a heterogeneous malignancy mainly caused by human papillomavirus (HPV). While a few studies have revealed heterogeneity of cervical cancer in chromosome levels, the correlation between genetic heterogeneity and HPV integration in cervical cancer remains unknown. Here, we applied multi-region whole-exome sequencing and HPV integration analysis to explore intratumor heterogeneity in cervical...

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Identifiers

PMID: 36635412
DOI: 10.1007/s12032-022-01942-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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