Article

Recurrent Integration of Human Papillomavirus Genomes at Transcriptional Regulatory Hubs

2021-08-31

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic human papillomavirus (HPV) genomes are often integrated into host chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single copy, or as tandem repeats of viral DNA interspersed with, or without, host DNA. Integration occurs frequently in common fragile sites susceptible to tandem repeat formation, and the flanking or interspersed host DNA often contains trans...

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Literature Corpus work: 829e2b99-d4b4-516b-999e-7ec64feaad90
DOI: 10.1101/2021.08.30.457540

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