Article

LDSC regression-based heritability estimates can be biased when summary statistics are obtained from meta-analysis or imputed variants

2026-07-09

Abstract excerpt

<h4>Motivation</h4> Linkage disequilibrium score (LDSC) regression is a popular method to estimate heritability for complex traits using summary statistics and linkage disequilibrium (LD) reference panels, offering a practical alternative to methods requiring individual-level data. Despite its widespread use, LDSC regression can produce biased heritability estimates. The properties of LDSC regression were investi...

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Literature Corpus work: 574008a8-f404-5a8c-9459-f3e28086a51c
DOI: 10.64898/2026.07.05.736573

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