Article

Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner

2023-05-24

Abstract excerpt

PARP1 is recruited and activated by DNA strand breaks, catalyzing the generation of poly-ADP-ribose (PAR) chains from NAD+. PAR relaxes chromatin and recruits other DNA repair factors, including XRCC1 and DNA Ligase 3, to maintain genomic stability. Here we show that, in contrast to the normal development of Parp1-null mice, heterozygous expression of catalytically inactive Parp1 (E988A, Parp1 +/A ) acts in a do...

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Identifiers and source

Literature Corpus work: 95971cd3-e015-5372-9819-54b8c4e38d08
DOI: 10.1101/2023.05.23.542022

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