Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination.

Nucleic acids research - 1 Sept 2003

Schultz Niklas, Lopez Elena, Saleh-Gohari Nasrollah, Helleday Thomas

Abstract excerpt

Cells with non-functional poly(ADP-ribose) polymerase (PARP-1) show increased levels of sister chromatid exchange, suggesting a hyper recombination phenotype in these cells. To further investigate the involvement of PARP-1 in homologous recombination (HR) we investigated how PARP-1 affects nuclea...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to DNA Repair
Share to Hydroxyurea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoquinolines

Share to Poly(ADP-ribose) Polymerase Inhibitors

Share to Poly(ADP-ribose) Polymerases

Share to Rad51 Recombinase

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 12930944
DOI: 10.1093/nar/gkg703
PMCID: PMC212803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12930944-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination.PMID 12930944Read ↗

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.Semantic proximity Read ↗

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.Semantic proximity Read ↗

Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.Semantic proximity Read ↗

Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative mannerSemantic proximity Read ↗

Involvement of poly(ADP-ribose) polymerase in base excision repair.Semantic proximity Read ↗

Knockout of Poly(ADP-ribose) polymerase 1 in human cell line: Influence on the Base Excision Repair Reactions in the Cellular ExtractsSemantic proximity Read ↗

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage.Semantic proximity Read ↗

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaksSemantic proximity Read ↗

Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase.Semantic proximity Read ↗

Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase InhibitionSemantic proximity Read ↗

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.Semantic proximity Read ↗

PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.