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Article

Beyond DNA Repair: Additional Functions of PARP-1 in Cancer

1 Jan 2013

Abstract excerpt

Poly(ADP-ribose) polymerases (PARPs) are DNA-dependent nuclear enzymes that transfer negatively charged ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide (NAD(+)) to a variety of protein substrates, altering protein-protein and protein-DNA interactions. The most studied of these enzymes is poly(ADP-ribose) polymerase-1 (PARP-1), which is an excellent therapeutic target in cancer due to its...

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Identifiers

PMID: 24350055
DOI: 10.3389/fonc.2013.00290

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