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Article

Transcriptional Roles of PARP1 in Cancer

11 Jun 2014

Abstract excerpt

Poly (ADP-ribose) polymerase-1 (PARP1) is an abundant, ubiquitously expressed NAD(+)-dependent nuclear enzyme that has prognostic value for a multitude of human cancers. PARP1 activity serves to poly (ADP-ribose)-ylate the vast majority of known client proteins and affects a number of cellular and biologic outcomes, by mediating the DNA damage response (DDR), base-excision repair (BER), and DNA strand break (DSB)...

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PMID: 24916104
DOI: 10.1158/1541-7786.mcr-13-0672

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