Article
Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2023
Shao Zhengping, Lee Brian J, Zhang Hanwen, Lin Xiaohui, Li Chen, Jiang Wenxia, Chirathivat Napon, Gershik Steven, Shen Michael M, Baer Richard, Zha Shan
Abstract excerpt
PARP1 (poly-ADP ribose polymerase 1) is recruited and activated by DNA strand breaks, catalyzing the generation of poly-ADP-ribose (PAR) chains from NAD+. PAR relaxes chromatin and recruits other DNA repair factors, including XRCC1 and DNA Ligase 3, to maintain genomic stability. Here we show that, in contrast to the normal development of Parp1-null mice, heterozygous expression of catalytically inactive Parp1...
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