Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PARP1: Liaison of Chromatin Remodeling and Transcription

27 Aug 2022

Abstract excerpt

Poly(ADP-ribosyl)ation (PARylation) is a covalent post-translational modification and plays a key role in the immediate response of cells to stress signals. Poly(ADP-ribose) polymerase 1 (PARP1), the founding member of the PARP superfamily, synthesizes long and branched polymers of ADP-ribose (PAR) onto acceptor proteins, thereby modulating their function and their local surrounding. PARP1 is the most prominent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36077699
DOI: 10.3390/cancers14174162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PARP1: Liaison of Chromatin Remodeling and TranscriptionPMID 36077699Read ↗

Transcriptional regulation mechanism of PARP1 and its application in disease treatmentSemantic proximity Read ↗

Novel insights into PARPs in gene expression: regulation of RNA metabolismSemantic proximity Read ↗

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and BeyondSemantic proximity Read ↗

A Double-Edged Sword: The Two Faces of PARylationSemantic proximity Read ↗

PARP (Poly ADP‐ribose Polymerase) Family in Health and DiseaseSemantic proximity Read ↗

Transcriptional Roles of PARP1 in CancerSemantic proximity Read ↗

The <scp>PARP</scp> family: insights into functional aspects of poly ( <scp>ADP</scp> ‐ribose) polymerase‐1 in cell growth and survivalSemantic proximity Read ↗

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.Semantic proximity Read ↗

PARP1 as an Epigenetic Modulator: Implications for the Regulation of Host-Viral DynamicsSemantic proximity Read ↗

The Multifactorial Role of PARP-1 in Tumor MicroenvironmentSemantic proximity Read ↗

Beyond PARP1: The Potential of Other Members of the Poly (ADP-Ribose) Polymerase Family in DNA Repair and Cancer TherapeuticsSemantic proximity Read ↗

Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.