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Article

Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.

Molecular cell - 7 Jan 2021

Li Tian, Wu Kun, Yue Zhenlei, Wang Yifei, Zhang Fan, Shen Huaizong

Abstract excerpt

Among the five KCNQ channels, also known as the Kv7 voltage-gated potassium (Kv) channels, KCNQ2-KCNQ5 control neuronal excitability. Dysfunctions of KCNQ2-KCNQ5 are associated with neurological disorders such as epilepsy, deafness, and neuropathic pain. Here, we report the cryoelectron microscopy (cryo-EM) structures of human KCNQ4 and its complexes with the opener retigabine or the blocker linopirdine at...

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PMID: 33238160
DOI: 10.1016/j.molcel.2020.10.037

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