Article

iPSC-derived extracellular vesicles rescue deficits in human and mouse models of Parkinson’s disease

2026-05-26

Abstract excerpt

Parkinson’s disease (PD) pathogenesis often involves progressive α-synuclein (α-Syn)-mediated neuronal dysfunction, yet the earliest cellular events that link α-Syn pathology to circuit failure remain poorly defined. Here, we used human induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons from patients carrying the familial A53T SNCA mutation to reconstruct a temporal course of dysfunction in vi...

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Literature Corpus work: 50724a6c-5273-5e4c-92c1-2eaf4c0a156e
DOI: 10.64898/2026.05.19.726142

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