Article

Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons

2024-09-20

Abstract excerpt

Parkinson’s disease (PD) involves multiple pathological processes in midbrain dopaminergic (mDA) neurons, including protein degradation defects, vesicular trafficking disruption, endolysosomal dysfunction, mitochondrial issues, and oxidative stress. Current PD models often lack complexity and focus on single phenotypes. We used patient-derived SNCA triplication (SNCA-4x) and isogenic control (SNCA-corr) mDA neuron...

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Literature Corpus work: 68b64d70-581a-59fe-9174-107442b84280
DOI: 10.1101/2024.09.19.613945

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